When placing an instance of ALyraCharacterWithAbilities on the map on the boundary between world partition cells, it fails to take damage in PIE. The expected attribute sets (HealthSet and CombatSet) are not registered in PIE for actors placed on world partition boundaries. See repro steps.
Expected: ALyraCharacterWithAbilities placed on world partition boundaries do have a registered HealthSet and CombatSet, and can take damage.
I found a faster repro
User's repro steps: "I was able to replicate the bug in a clean 5.2.1 Lyra project."
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-189824 in the post.