The Game view cannot be changed in Orthographic view despite that the Orthographic views can be affected by the game view options. This issue does not appear to be a regression.
Versions Tested: Issue occurs in all versions
4.16.3 - CL: 3561208
4.17.2 - CL: 3658906
4.18P2 - CL: 3660543
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-50566 in the post.