From a UDN user:
[Crash] Update Rate optimization enabled on b_hero_shootermannequin in LyraStartergame crashes
Hello,I haven't dug in to it yet, but with the Lyra Starter project if you enable Update rate optimizations on B_Hero_ShooterMannequin the game crashes on playing.
Crash is in UE::Anim::Attributes::InterpolateAttributes
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-162931 in the post.